Human T Cell
Dalazatide - a peptide therapeutic blocking the Kv1.3 channel in specific T cells
Dalazatide - a peptide therapeutic blocking the Kv1.3 channel in specific T cells
TEKv Therapeutics is a startup, biotech company based in Columbus, Ohio seeking to acquire, develop, and commercialize novel peptides to serve as therapeutics in the treatment of autoimmune and autoimmune-mediated diseases.
To develop and commercialize novel treatments for debilitating T cell mediated autoimmune diseases in a specific and selective way, striving to meet significant unmet medical needs.
Jack Tzagournis
150 E. Broad St.
Columbus, OH 43215
614-569-4321
Dalazatide, formerly ShK-186, is an optimized version of a peptide found in the venom of the Caribbean sea anemone, Stichodactyla Helianthus. Our drug candidate targets the Kv1.3 potassium ion channel that is critical to the function of immune cells that are auto-reactive, specifically effector memory T cells (TEM). These cells are believed to be integrally involved in the pathogenesis of many autoimmune diseases. Patients with certain active autoimmune diseases have increased numbers of the TEM cells that express Kv1.3, suggesting that blocking this channel could lead to inhibiting the inflammatory response and hopefully reverting the underlying disease. Dalazatide is a highly potent and selective peptide which importantly allows it to be immune sparing so that the immune system can continue to serve its protective function.
Dalazatide was well tolerated by volunteers in phase Ia and phase Ib clinical trials. Diseases where evidence has been found that this channel is up-regulated through ex vivo human tissue or in vivo in animals or both include; multiple sclerosis, ulcerative colitis, lupus nephritis, systemic lupus erythematosus (SLE), asthma, vasculitis, onset of type I diabetes, graft versus host disease, Crohn's disease, psoriasis, psoriatic arthritis, rheumatoid arthritis, alopecia aerate, myositis, inflammatory bowel disease, and Sezary Syndrome. We believe dalazatide could be a safer and more effective approach to treating these diseases.
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Last updated: 6/1/2020
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